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KMID : 1094020180350040150
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Journal of Veterinary Clinics
2018 Volume.35 No. 4 p.150 ~ p.154
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Chemotherapeutic Management in a Labrador Retriever with Cutaneous Nonepitheliotropic B-cell Lymphoma
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Hong Il-Hwa
Kim Min-Ju
Song Joong-Hyun
Hwang Tae-Sung
Lee Hee-Chun
Yu Do-Hyeon
Kang Byeong-Teck
Jung Dong-In
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Abstract
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A 9-month-old, castrated, male Labrador Retriever was referred for generalized progressing cutaneous reddishmass lesions with bleeding, scale, crust, and pruritus. On the basis of histopathological findings and the results ofimmunochemical staining, cutaneous nonepitheliotropic B-cell lymphoma was identified. A cyclophosphamide?doxorubicin?vincristine?prednisolone (CHOP)-based chemotherapy regimen was initiated, and the patient initiallyshowed partial response to vincristine and L-asparaginase, but the cutaneous lesions progressed gradually. After thefirst cycle of the CHOP-based protocol, lomustine was administered instead. The cutaneous lesions showed partialresponse to lomustine, but the treatment did not stop the progression of cutaneous lymphoma. The patient was euthanizeddue to neurologic signs, including reduced consciousness and seizures, 53 days after initial presentation. The postmortemhistopathological examination showed systemic metastasis involving the lymph nodes, skin, kidney, ureter, liver, brain,temporal muscle, diaphragmatic muscle, conjunctiva, and oral cavity.
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KEYWORD
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dog, cutaneous lymphoma, CHOP, lomustine (CCNU), B-cell
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